Mice Blk

Mouse


The AD unit can be used as an operant chamber for mice, as well as for other studies. The LT unit, a larger scale version of the AD unit with similar functionality, can be used for open field and novel object studies.

Both the AD and LT units have a base screen and an optional side screen to present visual stimuli, as well as providing the environment needed for reliable tracking of the animal, which could be used to create an activity heat-map.

Zantiks AD - mouse exploring 5-choice chamber

Mouse

Mice are used for research modelling human behaviour under physiological and pathological conditions, for screening therapeutic agents and for toxicology studies.

Many features at the anatomical, cellular and molecular level are common to mouse and humans. The mouse also shares many brain functions with humans, such as hunger, circadian rhythm, aggression, memory, sexual behaviour and emotional responses. In addition, more than 90% of the mouse and human genes are syntenic and nearly 99% of human genes have mouse equivalents.

Zantiks units can be used for various behavioural studies in mice.

  • Passive avoidance
  • Object recognition task
  • Open field
  • Light/Dark Transition test
  • 5-choice serial reaction time task (5-CSRTT)
  • Trial-unique, delayed nonmatching-to-location (TUNL)
  • Rodent continuous performance test (rCPT)
  • Y-maze spontaneous alternation: a test for measuring the eagerness of rodents to explore new environments. View the protocol here.
  • Two-choice discrimination task: a behavioural test for measuring discrimination and memory in rodents. View the protocol here.
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References

Tecott, L.H. (2003). The genes and brains of mice and men. American Journal of Psychiatry,160, 646–656.
Wilson, R.C., Vacek T., Lanier, D.L., & Dewsbury, D.A. (1976). Open-field behavior in muroid rodents. Behavioral Biology,17, 495–506. Van Meer, P., & Raber, J. (2005). Mouse behavioural analysis in systems biology. Biochemistry Journal, 389, 593–610.
Tremml, P., Lipp, H.P., Muller, U., Ricceri L., & Wolfer, D.P. (1998). Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified beta-amyloid precursor protein gene. Behavioral Brain Research, 95, 65–76.
Ennaceur, A., & Aggleton, J.P. (1997). The effects of neurotoxic lesions of the perirhinal cortex combined to fornix transection on object recognition memory in the rat. Behavioral Brain Research, 88, 181–193.
Hall, M.E., & Mayer, M.A. (1975). Effects of alpha methyl-para-tyrosine on the recall of a passive avoidance response. Pharmacology Biochemistry and Behavior, 3, 579–582.